Old Town (Czech: Staré Mesto) is a quarter in the city of Prague, Czech Republic.

Old Town was the original place of settlement in Prague. In the 14th century, Charles IV expanded the city by founding the New Town. The two parts are separated by Na Príkope street.

Notable places in the Old Town include the Old Town Square or Astronomical Clock. Across the river Vltava is the Lesser Quarter, called Malá Strana in Czech. These two parts of the town are connected by Charles Bridge.

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