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Online References



Animation Files

  • Molecular Motor (EcoR124I):

    The EcoR124I molecular motor  is a DNA translocase.  It attaches to DNA at a specific site (GAAnnnnnnRTCG - shown as a yellow cylinder in the movie) and 'pulls' the adjacent DNA through the bound complex, following the helical thread of the DNA, which will 'spin' an object attached to the DNA (illustrated by attaching a cube to the end of the DNA in this movie).  This produces a bionanoactuator, where the DNA can easily be surface attached - say at the left of the picture - and the nanoactuator pulls an object attached to the DNA toward that surface.


  • A surface attached DNA molecule, with a single binding site for the EcoR124I molecular motor, is stretched vertically by means of the magnetic bead attached at the far end of the DNA molecule, which in turn is held in an external magnetic field.  The EcoR124I molecular motor attaches to the DNA and pulls the bead until dissociation of the motor subunit releases the DNA and the process can repeat.
  • Device Prototypes:

     This animation shows the proposed single-molecule reporting system (incorporating the nanoactuator).  In this system the Hall Effect Sensors are shown red when the magnetic bead is moving toward them to indicate generation of an electrical signal.

  • Integrated device
    • 2D illustration
    • 3D animation
    • Full Scale Drawing


Status Reports

  • BioNano-Switch
    Status Reports
    • Mar 07
    • Sept 07
    • Mar 08 (Interim Project Review)
    • Sept 08
    • Mar 09
    • [1st Draft of Final Report]
    • Final Report